Identification of widespread ultra-edited human RNAs.
Adenosine-to-inosine modification of RNA molecules (A-to-I RNA editing) is an important mechanism that increases transciptome diversity.It occurs when a genomically encoded adenosine (A) is converted to an inosine (I) by ADAR proteins.Sequencing reactions read inosine as guanosine (G); therefore, current methods to detect A-to-I editing sites align